Source: Carel Official Technical Whitepaper
Reference: Cosmetics 2025, 12, 107.
In the evolution of modern skincare science, peptides have emerged as a new bridge connecting biology and beauty. Carel’s core technology system, PeptiFusion™, places peptides at the center as bioactive signaling molecules. Through a tri-core synergy mechanism, it achieves systematic repair and revitalization of the skin’s structure and function.
1. Peptides: The Molecular Language of Precision Skincare
Peptides, composed of 2–50 amino acids, are both fragments of proteins and signaling molecules that mediate communication among skin cells.
By binding to specific receptors, they regulate key physiological processes such as collagen synthesis, inflammation control, antioxidant defense, and barrier restoration.
In traditional formulations, peptides were mostly confined to the realm of anti-aging.
Through the PeptiFusion™ tri-core system, Carel extends their benefits into anti-aging, brightening, repairing, and moisturizing, redefining how peptides serve the skin on multiple levels.
2. The PeptiFusion™ Tri-Core Synergy Mechanism
Carel’s formula combines active peptides as the Signal Core, synergized with the Functional Active Core (Lingzhi Extract) and the Localized Adaptation Core (Bio-Delivery System) to form a dynamic skincare mechanism network.
Within this system:
- Peptide Signal Core: Activates fibroblasts and promotes collagen and elastin synthesis.
- Functional Active Core: Derived from Lingzhi spore extracts, regulates inflammation and oxidative stress to enhance repair.
- Localized Adaptation Core: Uses bio-delivery carriers to optimize absorption and ensure compatibility with various climates and skin conditions.
This mechanism elevates Carel’s formulas from ingredient stacking to structural synergy, achieving true translation of science from molecular to dermal levels.
3. The Five Biological Pathways of Peptides
As illustrated in Figure 1, peptides function across multiple skin dimensions — anti-aging, brightening, repairing, moisturizing, and antimicrobial defense.
Major physiological functions of peptides in skincare (from Cosmetics 2025, 12, 107).
Anti-Aging
- Palmitoyl Pentapeptide-4 (KTTKS): Stimulates collagen synthesis while inhibiting collagenase activity.
- Acetyl Hexapeptide-8: Reduces expression lines by modulating neurotransmitter release mechanisms.
Brightening
- Tetrapeptide-30 (PKEK): Inhibits the α-MSH signaling pathway, reducing melanin synthesis and transfer.
- Low-molecular-weight peptides: Bind to copper ions in tyrosinase, suppressing its catalytic activity and slowing pigmentation at the source.
Repairing
- Copper Tripeptide (Cu-GHK): Promotes wound healing and the expression of DNA repair-related genes.
- Simultaneously downregulates inflammatory cytokines (IL-6, TNF-α), rebuilding a resilient skin barrier.
Moisturizing
- Certain peptides upregulate hyaluronic acid synthase, boosting HA production.
- Others activate aquaporins, improving water transport and barrier hydration.
Antimicrobial
- Antimicrobial peptides (AMPs): Provide natural defense against microorganisms and help maintain the skin’s microbiome balance.
4. Peptide Applications Across Carel’s Product Lines
Carel applies this scientific framework across its hero collections, forming a “Peptide × Botanical × Delivery” synergy model:
5. AI-Driven Molecular Innovation
Carel integrates next-generation AI molecular modeling systems to accelerate peptide innovation.
Through structural generation algorithms such as RFdiffusion and ChemOrchestra, Carel achieves:
- Intelligent Peptide Screening: Predicts affinity between peptides and biological targets (e.g., TGF-β, COL1A1).
- Stability Modeling: Uses molecular dynamics simulations to optimize cyclic or D-amino-acid-modified peptides.
- Absorption Efficiency Assessment: Simulates stratum corneum diffusion kinetics to enhance bioavailability and skin penetration.
This AI-centered workflow empowers Carel to develop proprietary skincare-grade peptide molecules, reducing R&D cycles from months to weeks.
6. From Laboratory to Skin: The Journey of Applied Science
Carel believes that beauty is not just a sensory perception — it is the reconstruction of biological equilibrium.
Through the multi-layered structural design of PeptiFusion™, Carel is leading skincare into a new era — shifting from sensory experience to structural repair.
Every drop of essenceis the convergence of science and warmth.
Science empowers beauty, perfectly attuned to nature — not just a brand statement, but an ongoing scientific pursuit.
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